منابع مشابه
Narrow vs broad-spectrum antimicrobial therapy for children hospitalized with pneumonia.
BACKGROUND The 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America community-acquired pneumonia (CAP) guideline recommends narrow-spectrum antimicrobial therapy for most children hospitalized with CAP. However, few studies have assessed the effectiveness of this strategy. METHODS Using data from 43 children's hospitals, we conducted a retrospective cohort study t...
متن کاملEnglish Listeners' Knowledge of the Broad versus Narrow Focus Contrast
The present study examined English listeners‟ knowledge of how the size of the focus constituent is expressed prosodically. Thirty English-speaking listeners participated in a prominence-rating experiment in which they heard the same production of a simple SVO answer sentence in different focus (i.e., different question) contexts. It was found that when the object was narrowly focused, it was h...
متن کاملEffect of Regulatory Architecture on Broad versus Narrow Sense Heritability
Additive genetic variance (VA ) and total genetic variance (VG ) are core concepts in biomedical, evolutionary and production-biology genetics. What determines the large variation in reported VA /VG ratios from line-cross experiments is not well understood. Here we report how the VA /VG ratio, and thus the ratio between narrow and broad sense heritability (h(2) /H(2) ), varies as a function of ...
متن کاملNarrow Vs Broad-spectrum Antimicrobial Therapy for Children Hospitalized With Pneumonia WHAT’S KNOWN ON THIS SUBJECT: Recent guidelines for the management of childhood pneumonia recommend narrow-spectrum
BACKGROUND: The 2011 Pediatric Infectious Diseases Society/Infectious Diseases Society of America community-acquired pneumonia (CAP) guideline recommends narrow-spectrum antimicrobial therapy for most children hospitalized with CAP. However, few studies have assessed the effectiveness of this strategy. METHODS: Using data from 43 children’s hospitals, we conducted a retrospective cohort study t...
متن کاملLargazole: from discovery to broad-spectrum therapy.
The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transformed cells. The intriguing structure and biological activity of largazole have ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1982
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/9.4.247